Dichloromethane → HCID 58934553, compound

Participants

Reaction Steps

To a solution of 1.0 g (3.5 mmol) of ethyl 6-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate in 10 mL of anhydrous dichloromethane was added a solution of 1.5 mL (30 mmol) of iodomonochloride in 5 mL anhydrous dichloromethane. The resulting brown solution was stirred at room temperature for one hour. The reaction was added to 50 mL of ethyl acetate. The organic solution was washed with sat. sodium sulfite solution three times, washed with brine three times and dried over anhydrous magnesium sulfate. Concentration in vacuo afforded 0.8 g (64%) of a yellow solid: 1H NMR (CDC3/300 MHz) 8.00 (s, 1H), 7.01(s, 1H), 5.81(s, 1H), 5.70(q, J=6.6 Hz, 1H), 4.38(m, 2H), 1.40(t, J=7.2 Hz, 3H); MS (ESI+) 357.0 (M+1, 100).

Provenance & Evidence