Sodium Hydroxide → HCID 69516683, compound

HRID 855036Notes

Reaction equation

HRID 855036 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([Cl:22])[CH:8]=[C:9]2[C:14]=1[O:13][CH:12]([C:15]([F:18])([F:17])[F:16])[C:11]([C:19]([OH:21])=[O:20])=[CH:10]2)#[C:2][CH2:3][CH3:4].[OH-].[Na+:24]>C(O)C>[C:1]([C:5]1[CH:6]=[C:7]([Cl:22])[CH:8]=[C:9]2[C:14]=1[O:13][CH:12]([C:15]([F:16])([F:17])[F:18])[C:11]([C:19]([O-:21])=[O:20])=[CH:10]2)#[C:2][CH2:3][CH3:4].[Na+:24]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58934444HCID 58934444, compound

Product 1

HCID 69516683HCID 69516683, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 75.8 mg (0.229 mmole) of 8-but-1-ynyl-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid in 2.0 mL of ethanol was treated with 2.274 mL of0.1008N NaOH. The resultant mixture was lyophilized to provide a quantitative yield of a yellow solid: 1H NMR (CD3OD/400 MHz) 1.22 (t, 3H, J=7.6 Hz), 2.44 (q, 2H, J=7.6 Hz), 5.88 (q, 1H J=7.2 Hz), 7.17-7.19 (m, 2H), 7.32 (s, 1H).

Sources & evidence

ORD record
ord-99bf6e9b62d34303a89d2e8ce1698a92
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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