Sodium Hydroxide → Sodium 6-chloro-8-[(2-fluorophenyl)ethynyl]-2-(trifluoromethyl)-2H-chromene-3-Carboxylate

HRID 855037Notes

Reaction equation

HRID 855037 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]#[C:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[F:20])[CH:11]=1)[O:8][CH:7]([C:21]([F:24])([F:23])[F:22])[C:6]([C:25]([OH:27])=[O:26])=[CH:5]2.[OH-].[Na+:29]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]#[C:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[F:20])[CH:11]=1)[O:8][CH:7]([C:21]([F:23])([F:24])[F:22])[C:6]([C:25]([O-:27])=[O:26])=[CH:5]2.[Na+:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 112579916-chloro-8-[(2-fluorophenyl)ethynyl]-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid

Product 1

HCID 69517542Sodium 6-chloro-8-[(2-fluorophenyl)ethynyl]-2-(trifluoromethyl)-2H-chromene-3-Carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 84.3 mg (0.213 mmole) of 6-chloro-8-[(2-fluorophenyl)ethynyl]-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid in 2.0 mL of ethanol was treated with 2.108 mL of 0.1008N NaOH. The resultant mixture was lyophilized to provide a quantitative yield of a yellow solid: 1H NMR (CD3OD/400 MHz) 5.97 (q, 1H, J=7.2 Hz), 7.14-7.20 (m, 2H), 7.28-7.30 (m, 1H), 7.36-7.42 (m, 3H), 7.51-7.54 (m, 1H).

Sources & evidence

ORD record
ord-89a43013171e4ece8ffb2f70f2db9244
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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