Sodium Hydroxide → HCID 69517471, compound

HRID 855038Notes

Reaction equation

HRID 855038 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([F:19])[CH:13]=3)[CH:11]=1)[O:8][CH:7]([C:20]([F:23])([F:22])[F:21])[C:6]([C:24]([OH:26])=[O:25])=[CH:5]2.[OH-].[Na+:28]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([F:19])[CH:13]=3)[CH:11]=1)[O:8][CH:7]([C:20]([F:22])([F:23])[F:21])[C:6]([C:24]([O-:26])=[O:25])=[CH:5]2.[Na+:28]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 51003555HCID 51003555, compound

Product 1

HCID 69517471HCID 69517471, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 52.0 mg (0.135 mmole) of 6-chloro-8-(3-fluoro-4-methylphenyl)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid in 2.0 mL of ethanol was treated with 1.334 mL of 0.1008N NaOH. The resultant mixture was lyophilized to provide a quantitative yield of a yellow solid: 1H NMR (CD3OD/400 MHz) 2.29 (d, 3H, J=1.6 Hz), 5.84 (q, 1H, J=7.2 Hz), 7.17-7.20 (m, 2H), 7.24-7.29 (m, 3H), 7.40 (s, 1H).

Sources & evidence

ORD record
ord-3e039d8721604ec3809661df942f5e72
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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