Sodium Hydroxide → HCID 69517532, compound

HRID 855039Notes

Reaction equation

HRID 855039 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH2:18][CH3:19])=[CH:14][CH:13]=3)[CH:11]=1)[O:8][CH:7]([C:20]([F:23])([F:22])[F:21])[C:6]([C:24]([OH:26])=[O:25])=[CH:5]2.[OH-].[Na+:28]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]3[CH:13]=[CH:14][C:15]([CH2:18][CH3:19])=[CH:16][CH:17]=3)[CH:11]=1)[O:8][CH:7]([C:20]([F:23])([F:21])[F:22])[C:6]([C:24]([O-:26])=[O:25])=[CH:5]2.[Na+:28]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53324454HCID 53324454, compound

Product 1

HCID 69517532HCID 69517532, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 6-chloro-8-(4-ethylphenyl)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid 51.9 mg (0.136 mmole) in 2.0 mL of ethanol was treated with 1.345 mL of 0.1008N NaOH. The resultant mixture was lyophilized to provide a quantitative yield of a yellow solid: 1H NMR (CD3OD/400 MHz) 1.25 (t, 3H, J=7.6 Hz), 2.67 (q, 2H, J=7.6 Hz), 5.82 (q, 1H, J=7.2 Hz), 7.21-7.25 (m, 4H), 7.38-7.40 (m, 3H).

Sources & evidence

ORD record
ord-bf3227c37d644dfeb0af6fd6cb267a30
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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