Sodium Hydroxide → HCID 69517985, compound

HRID 855040Notes

Reaction equation

HRID 855040 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([CH3:19])[CH:13]=3)[CH:11]=1)[O:8][CH:7]([C:20]([F:23])([F:22])[F:21])[C:6]([C:24]([OH:26])=[O:25])=[CH:5]2.[OH-].[Na+:28]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([CH3:19])[CH:13]=3)[CH:11]=1)[O:8][CH:7]([C:20]([F:22])([F:23])[F:21])[C:6]([C:24]([O-:26])=[O:25])=[CH:5]2.[Na+:28]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58934770HCID 58934770, compound

Product 1

HCID 69517985HCID 69517985, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 6-chloro-8-(4-chloro-3-methylphenyl)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid 31.5 mg (0.078 mmole) in 2.0 mL of ethanol was treated with 0.775 mL of 0.1008N NaOH. The resultant mixture was lyophilized to provide a quantitative yield of a yellow solid: 1H NMR (CD3OD/400 MHz) 2.39 (s, 3H), 5.77 (q, 1H, J=6.8 Hz), 7.25-7.28 (m, 1H), 7.34 (d, 1H, J=2.4 Hz), 7.37-7.40 (m, 3H), 7.79 (s, 1H).

Sources & evidence

ORD record
ord-75a4924e654046a9950ade73623abf5e
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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