Sodium Hydroxide → HCID 69517151, compound

HRID 855041Notes

Reaction equation

HRID 855041 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([CH3:20])[CH:13]=3)[CH:11]=1)[O:8][CH:7]([C:21]([F:24])([F:23])[F:22])[C:6]([C:25]([OH:27])=[O:26])=[CH:5]2.[OH-].[Na+:29]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([CH3:20])[CH:13]=3)[CH:11]=1)[O:8][CH:7]([C:21]([F:24])([F:22])[F:23])[C:6]([C:25]([O-:27])=[O:26])=[CH:5]2.[Na+:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 51003556HCID 51003556, compound

Product 1

HCID 69517151HCID 69517151, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 6-chloro-8-(4-methoxy-3-methylphenyl)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid 46.6 mg (0.117 mmole) in 2.0 mL of ethanol was treated with 1.160 mL of 0.1008N NaOH. The resultant mixture was lyophilized to provide a quantitative yield of a yellow solid: 1H NMR (CD3OD/400 MHz) 2.20 (s, 3H), 3.85 (s, 3H), 5.77 (q, 1H, J=6.8 Hz), 6.93 (d, 1H, J=8.0 Hz), 7.26-7.32 (m, 4H), 7.78 (s, 1H).

Sources & evidence

ORD record
ord-b7efb868a3874bf39607f3179d907934
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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