Benzoyl Peroxide → HCID 86599573, compound

Participants

Reaction Steps

The ester from Step 1 (2.1 g, 4.25 mmol) was dissolved in toluene (15 mL). The Et3SiH (30 mL, 0.18 mol) was added to above solution. The mixture was heated to reflux. The benzoyl peroxide (1.03 g, 4.25 mmol) in toluene (15 mL) was added in 4 portions at 15 min intervals. The mixture was heated to reflux for 2 hours and stirred at r.t overnight. The mixture was passed through silic plug and plug was washed with 5% to 10% EtOAc in hexane to give crude product: LCMS m/z 369.15 (M+H). This ester was of suitable purity to use without further purification.

Provenance & Evidence