Lithium Hydroxide → HCID 58934991, compound

Participants

Reaction Conditions

Reaction Steps

The ester from Example 9s, Step 5 was added THF(7): EtOH(2): H2O(1) followed by LiOH (1.5 eq) and heated to 40° C. for 4 h. The reaction was cooled to room temperature, concentrated in vacuo. Acidified with HCl conc to pH 1, filtered solid and subjected solid to preparative reverse phase chromatography to produce the title compound (93%): ESHRMS m/z 361.1062 (M−H, C20H16O3F3Calc'd 361.1046). 1HNMR (DMSO-d6/400 MHz), 13.19 (s, 1H), 7.77 (s, 1H), 7.33 (d, 1H, J=7.6 Hz), 7.00 (m, 3H), 6.77 (d, 1H, J=7.7 Hz), 6.70 (s, 1H), 5.82 (q, 1H, J=7.1 Hz), 3.87 (s, 2H), 2.2 (s, 3H), 2.10 (s, 3H).

Provenance & Evidence