(+)-1-(1-Naphthyl)ethylamine → HCID 58934803, compound

Participants

Reaction Steps

A racemic mixture of the compound prepared in Example 42a, Step 2 was chirally resolved using the same protocol as for Example 609e, Step 1, R-enantiomer was identified as peak 1 with retention time 5.45 min: ESHRMS m/z 347.0875 (M−H, C19H14F3O3 Calc'd 347.0890). 1HNMR (DMSO-d6/400 MHz) 13.19 (brs, 1H), 7.74 (s, 1H), 7.11-7.27 (m, 6H), 6.74 (q, 1H, J=7.1 Hz), 3.91 (s, 2H), 2.11 (s, 3H). R-isomer: 19FNMR (d6-benzene; 6 eq of (R)-(+)-1-(1-naphthyl)ethylamine) d −77.76 (d, 3F, J=6.8 Hz, R-enantiomer), −77.74 (d, 3F, J=6.8 Hz, S-enantiomer).

Provenance & Evidence