HCID 86599495, compound → HCID 58934665, compound

HRID 855119Notes

Reaction equation

HRID 855119 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([O:28][C:29]([F:32])([F:31])[F:30])[CH:12]=[C:13]3[C:18]=2[O:17][CH:16]([C:19]([F:22])([F:21])[F:20])[C:15]([C:23]([O:25]CC)=[O:24])=[CH:14]3)=[CH:3][CH:2]=1>CC(O)=O>[N:1]1[CH:6]=[CH:5][C:4]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([O:28][C:29]([F:32])([F:30])[F:31])[CH:12]=[C:13]3[C:18]=2[O:17][CH:16]([C:19]([F:22])([F:21])[F:20])[C:15]([C:23]([OH:25])=[O:24])=[CH:14]3)=[CH:3][CH:2]=1

Participants

3

Reactant 1

HCID 86599495HCID 86599495, compound

Product 1

HCID 58934665HCID 58934665, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The ester from Step 1 was hydrolyzed via a method similar to that described in Example 621c, Step 2 using HOAc in the acidification step to give the product as a pale yellow solid: ESHRMS m/z 430.0531 (M+H, C19H10F6NO4, Calc'd 430.0509); 1H NMR (dmso-d6, 300 MHz) 14.5 (brs, 1H), 8.64 (d, 2H, J=5.7 Hz), 7.58-7.48 (m, 5H), 6.08 (q, 1H, J=7.3 Hz).

Sources & evidence

ORD record
ord-39998634668c4549aeedd02766e3d213
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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