Lithium Hydroxide → HCID 58934502, compound

Participants

Reaction Conditions

Reaction Steps

To 0.090 g (0.24 mmol) of ethyl 8-methyl-7-phenoxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate in 5 mL THF:EtOH:H2O (7:2:1) was added 0.015 g (0.36 mmol) of LiOH. The mixture was heated at 60° C. for 2 hours. Removed volatiles in vacuo and diluted with HCl (10%), CH3CN, and DMF and purified by reverse phase chromatography to afford 0.046 g (55%) of a pale yellow solid: 11H NMR (CH3OD/400 MHz) 2.15 (s, 3H), 5.79 (q, 1H, J=7.2 Hz), 6.43 (d, 1H, J=8.4 Hz), 6.94-6.96 (m, 2H), 7.09-7.14 (m, 2H), 7.33-7.37 (m, 2H), 7.74 (s, 1H); MS (ES+) 351.2 (M+H, 100); HRMS (ES−) m/z calcd for (C18H13F3O4) 349.0688, found 349.0681.

Provenance & Evidence