Sodium Hydroxide → HCID 23687344, compound

Participants

Reaction Steps

To a solution of 116 mg of 7-(2,5-dimethylphenoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid (0.318 mmol) in 4 mL of ethanol and 2 mL of THF was added 3.15 mL (0.318 mmol) of a 0.1008 N NaOH solution in water. The resulting solution was stirred at room temperature for 15 min. The volatiles were removed. To the solution was added 2 mL of water and the resulting suspension was cooled at −78° C. and solidified then put on high vacuum for lyophilization. The ivory solid was registered as PHA-807535A: 1H NMR (CD3OD/400 MHz) 2.08 (s, 3H), 2.28 (s, 3H), 5.77 (q, 1H, J=7.6 Hz), 6.31 (d, 1H, J=2.0 Hz), 6.41 (dd, 1H, J=2.4 Hz, 8.4 Hz), 6.78 (s, 1H), 6.94 (d, 1H, J=8.0 Hz), 7.11-7.15 (m, 2H), 7.38 (s, 1H); MS (ES+) 365 (M+l, 100); LC-MS purity 100% at 3.575 min. (UV), 100% ELSD.

Provenance & Evidence