Sodium Hydroxide → HCID 86599507, compound

Participants

Reaction Steps

A solution of 50.0 mg (0.165 mmole) of (2S)-(-)-8-chloro-6-ethynyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid in 1.5 mL of ethanol was treated with 1.64 mL of 0.1008N NaOH. The resultant mixture was lyophilized to provide 39.0 mg (quant.) of an yellow solid: MS (ES+) 303 (M+1, 100); 1H NMR (CD3OD/400 MHz) 5.95 (q, 1H, J=7.1 Hz), 7.29 (d, 1H, J=1.8 Hz), 7.37 (s, 1H), 7.39 (d, 1H, J=1.8 Hz); 19F NMR (CD3OD/400 MHz) 80.3 (d, 3F, J=6.8 Hz).

Provenance & Evidence