p-(Trifluoromethoxy)benzaldehyde → HCID 86603034, compound

HRID 855189Notes

Reaction equation

HRID 855189 reaction equation
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[CH:6][CH:5]=1.[F:14][C:15]([F:26])([F:25])[C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][NH2:24])[CH:19]=[CH:20][CH:21]=1>>[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH2:8][NH:24][CH2:23][CH2:22][C:18]2[CH:19]=[CH:20][CH:21]=[C:16]([C:15]([F:14])([F:25])[F:26])[CH:17]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 69573p-(Trifluoromethoxy)benzaldehydeHCID 104223Phenethylamine, m-trifluoromethyl-

Product 1

HCID 86603034HCID 86603034, compound

Procedure

(4-trifluoromethoxy-benzyl)-[2-(3-trifluoromethyl-phenyl)-ethyl]-amine was synthesized in analogy to the above procedure using 1.232 g 4-(trifluoromethoxy)benzaldehyde (6.48 mmol) and 0.817 g 2-(3-trifluoromethyl-phenyl)-ethylamine (4.32 mmol), 1.31 g (83%) of a light yellow liquid were obtained. MS: 364 (M+H)+.

Sources & evidence

ORD record
ord-256fa2fe247242d09e13f4095b0b93cb
Source dataset
uspto-grants-2007_08
Patent number
US07259183B2

Reaction notes

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