反应详情

The title compound was synthesized in analogy to (4-cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine (described in example S53) using 4-(1-methyl-cyclo-propyl)-benzaldehyde (150 mg, 0.94 mmol), 2-(3-trifluoromethylphenyl)-ethylamine (177 mg, 0.94 mmol) and sodium borohydride (53 mg, 1.40 mmol). The isolated residue was purified by flash column chromatography (2%-5% MeOH in EtOAc) to give the desired product (195 mg, 62%) as a colorless oil. MS (ISP) 334.3 (M+H)+.

1. customThe isolated residue was purified by flash column chromatography (2%-5% MeOH in EtOAc)