HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dichlorophenethylamine → [2-(3,4-Dichlorophenyl)-ethyl]-[4-(1,1-dimethylpropyl)-benzyl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dichlorophenethylamine | HCID 217958 | — |
| Reactant | 4-(2-Methylbutan-2-yl)benzaldehyde | HCID 473780 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | (4-Cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine | HCID 69342889 | — |
| Product | [2-(3,4-Dichlorophenyl)-ethyl]-[4-(1,1-dimethylpropyl)-benzyl]-amine | HCID 69342919 | 97% |
Reaction Steps
The title compound was synthesized in analogy to (4-cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine (described in example S53) using 4-(1,1-dimethylpropyl)-benzaldehyde (87.5 mg, 0.50 mmol), 2-(3,4-dichlorophenyl)-ethylamine (94 mg, 0.50 mmol) and sodium borohydride (28 mg, 0.75 mmol). The desired product (169 mg, 97%) was isolated without further purification as a colorless oil. MS (ISP) 350.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259183B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-5c9c6e8d63004548a552a8ea3fc5d344 |
| Source note | uspto-grants-2007_08 |