化工社化工社 化学情報印刷レポート · 研究参考用
Phenethylamine, m-trifluoromethyl- → [4-(1,1-Dimethylpropyl)-benzyl]-[2-(3-trifluoromethylphenyl)-ethyl]-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenethylamine, m-trifluoromethyl- | HCID 104223 | — |
| 反応物 | 4-(2-Methylbutan-2-yl)benzaldehyde | HCID 473780 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | (4-Cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine | HCID 69342889 | — |
| 生成物 | [4-(1,1-Dimethylpropyl)-benzyl]-[2-(3-trifluoromethylphenyl)-ethyl]-amine | HCID 69341945 | 94% |
反応手順
The title compound was synthesized in analogy to (4-cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine (described in example S53) using 4-(1,1-dimethylpropyl)-benzaldehyde (prepared as described in example S103) (88 mg, 0.50 mmol), 2-(3-trifluoromethylphenyl)-ethylamine (94 mg, 0.50 mmol) and sodium borohydride (28 mg, 0.75 mmol). The desired product (163 mg, 94%) was isolated without further purification as a colorless oil. MS (ISP) 350.3 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07259183B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-8531210324f84aca98814047268ec9b2 |
| 出典メモ | uspto-grants-2007_08 |