HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenethylamine, m-trifluoromethyl- → HCID 69342519, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenethylamine, m-trifluoromethyl- | HCID 104223 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | (4-Cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine | HCID 69342889 | — |
| Reactant | 3-Chloro-4-(1-methylcyclopropyl)-benzaldehyde | HCID 86093823 | — |
| Product | HCID 69342519 | HCID 69342519 | 89% |
Reaction Steps
The title compound was synthesized in analogy to (4-cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine (described in example S53) using 3-chloro-4-(1-methylcyclopropyl)-benzaldehyde (86 mg, 0.44 mmol), 2-(3-trifluoromethylphenyl)-ethylamine (84 mg, 0.44 mmol) and sodium borohydride (25 mg, 0.66 mmol). The desired product (145 mg, 89%) was isolated without further purification as a colorless oil. MS (ISP) 368.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259183B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-f0efd25bde0a48b785a02f40c255bb90 |
| Source note | uspto-grants-2007_08 |