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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 855318Generated: October 30, 2026

Phenethylamine, m-trifluoromethyl- → HCID 69342491, compound

https://huagongshe.com/reaction/855318

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenethylamine, m-trifluoromethyl-HCID 104223—
ReactantSodium borohydrideHCID 4311764—
ReactantHCID 22259691HCID 22259691—
Reactant(4-Cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amineHCID 69342889—
ProductHCID 69342491HCID 6934249196%

Reaction Steps

The title compound was synthesized in analogy to (4-cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine (described in example S53) using 4-tert-butyl-3-chloro-benzaldehyde (68 mg, 0.35 mmol), 2-(3-trifluoromethyl-phenyl)-ethylamine (65 mg, 0.35 mmol) and sodium borohydride (20 mg, 0.52 mmol). The desired product (123 mg, 96%) was isolated without further purification as a colorless oil. MS (ISP) 370.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07259183B2
Source datasetuspto-grants-2007_08
ORD IDord-ab28e6b24ef245288726014e53de35e8
Source noteuspto-grants-2007_08