HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dichlorophenethylamine → (4-Cyclopentyl-benzyl)-[2-(3,4-dichloro-phenyl)-ethyl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dichlorophenethylamine | HCID 217958 | — |
| Reactant | p-Cyclopentylbenzaldehyde | HCID 3016187 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | (4-Cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine | HCID 69342889 | — |
| Product | (4-Cyclopentyl-benzyl)-[2-(3,4-dichloro-phenyl)-ethyl]-amine | HCID 69342726 | — |
Reaction Steps
The title compound was synthesized in analogy to (4-cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine (described in example S53) using 160 mg of 4-cyclopentyl-benzaldehyde (0.92 mmol), 175 mg of 2-(3,4-dichloro-phenyl)-ethylamine (0.92 mmol) and 52 mg of sodium borohydride (1.38 mmol). The isolated light yellow oil (183 mg, 57%) was used in the following step without further purification. MS (ISP) 348.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259183B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-807d72f3e1724f80ab383e4721d7037b |
| Source note | uspto-grants-2007_08 |