Phenethylamine, m-trifluoromethyl- → HCID 86603042, compound

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Reaction Steps

The title compound was synthesized in analogy to N-[2-(3,4-dichloro-phenyl)-ethyl]-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-benzamide (described in example S98) using 250 mg of 3-chloro-4-trifluoromethyl-benzoic acid (1.11 mmol) and 221 mg (1.17 mmol) of 2-(3-trifluoromethylphenyl)-ethylamine. The isolated residue was purified by flash column chromatography to give 360 mg of 3-chloro-4-trifluoromethyl-N-[2-(3-trifluoromethyl-phenyl)-ethyl]-benzamide (82%) as a yellow solid.

Provenance & Evidence