HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86603040, compound → HCID 86603043, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86603040 | HCID 86603040 | — |
| Reactant | HCID 86603042 | HCID 86603042 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86603043 | HCID 86603043 | 93% |
Reaction Steps
The title compound was synthesized in analogy to [2-(3,4-dichloro-phenyl)-ethyl]-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-benzyl]-amine (described in example S98) using 200 mg of 3-chloro-4-trifluoromethyl-N-[2-(3-trifluoromethyl-phenyl)-ethyl]-benzamide (0.51 mmol) and 2.02 ml of a 1 molar solution of BH3-THF complex in THF. The isolated residue was purified by flash column chromatography to give 180 mg of (3-chloro-4-trifluoromethyl-benzyl)-[2-(3-trifluoromethyl-phenyl)-ethyl]-amine (93%) as a colorless oil. MS (ISP) 382.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259183B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-d3406f4e707a4c198b89353babe035ac |
| Source note | uspto-grants-2007_08 |