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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 855339Generated: October 28, 2026

HCID 86603040, compound → HCID 86603043, compound

https://huagongshe.com/reaction/855339

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 86603040HCID 86603040—
ReactantHCID 86603042HCID 86603042—
SolventTetrahydrofuranHCID 8028—
ProductHCID 86603043HCID 8660304393%

Reaction Steps

The title compound was synthesized in analogy to [2-(3,4-dichloro-phenyl)-ethyl]-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-benzyl]-amine (described in example S98) using 200 mg of 3-chloro-4-trifluoromethyl-N-[2-(3-trifluoromethyl-phenyl)-ethyl]-benzamide (0.51 mmol) and 2.02 ml of a 1 molar solution of BH3-THF complex in THF. The isolated residue was purified by flash column chromatography to give 180 mg of (3-chloro-4-trifluoromethyl-benzyl)-[2-(3-trifluoromethyl-phenyl)-ethyl]-amine (93%) as a colorless oil. MS (ISP) 382.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07259183B2
Source datasetuspto-grants-2007_08
ORD IDord-d3406f4e707a4c198b89353babe035ac
Source noteuspto-grants-2007_08