5-chloro-1H-indole-7-carboxylic acid [2-(3-benzyloxy-phenyl)-ethyl]-(4-tert-butyl-benzyl)-amide → HCID 86603055, compound

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Reaction Steps

200 mg of 5-chloro-1H-indole-7-carboxylic acid [2-(3-benzyloxy-phenyl)-ethyl]-(4-tert-butyl-benzyl)-amide (0.36 mmol) were dissolved in 20 ml EtOAc and hydrogenated for 5 h over 20 mg Pd/C 10%. After removal of the catalyst by filtration, the solution was concentrated in vacuo and the residue purified by column chromatography (8 g silicagel, heptane/EtOAc 2:1) leading to 136 mg of 5-chloro-1H-indole-7-carboxylic acid (4-tert-butyl-benzyl)-[2-(3-hydroxy-phenyl)-ethyl]-amide (79%) as a light yellow solid. MS (ISP) 461.4 (M+H)+.

Provenance & Evidence