Dichloromethane → HCID 86603104, compound

Participants

Role	Name	HCID	Charge
Reactant	Dichloromethane	HCID 6344	—
Reactant	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Reactant	(4-Tert-butylbenzyl)-[2-(4-chlorophenyl)-ethyl]-amine	HCID 29792506	—
Reactant	4-Chloro-1H-indole-7-carboxylic acid	HCID 69346850	—
Product	HCID 86603104	HCID 86603104	72.3%

Reaction Steps

To a solution of 64 mg (0.33 mmol) of 4-chloro-1H-indole-7-carboxylic acid and 91 mg (0.3 mmol) of (4-tert-butyl-benzyl)-[2-(4-chloro-phenyl)-ethyl]-amine in 3 ml DCM 63 mg (0.33 mmol) of EDC.HCl were added and the reaction mixture was stirred over night at rt. The product was purified by column chromatography (25 g silica gel; heptane/EtOAc 7:3) to yield 104 mg (72%) product as a light yellow foam. MS (ISP) 479.1 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07259183B2
Source dataset	uspto-grants-2007_08
ORD ID	ord-ca7d7f3976b249e69e1e4808370c8cc7
Source note	uspto-grants-2007_08