HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 4-Fluoro-1H-indole-7-carboxylic acid (4-tert-butyl-benzyl)-[2-(4-chloro-phenyl)-ethyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 4-fluoro-1H-indole-7-carboxylic Acid | HCID 11579217 | — |
| Reactant | (4-Tert-butylbenzyl)-[2-(4-chlorophenyl)-ethyl]-amine | HCID 29792506 | — |
| Product | 4-Fluoro-1H-indole-7-carboxylic acid (4-tert-butyl-benzyl)-[2-(4-chloro-phenyl)-ethyl]-amide | HCID 86603107 | 81.4% |
Reaction Steps
To a solution of 59 mg (0.33 mmol) of 4-fluoro-1H-indole-7-carboxylic acid and 91 mg (0.3 mmol) of (4-tert-butyl-benzyl)-[2-(4-chloro-phenyl)-ethyl]-amine in 3 ml DCM 63 mg (0.33 mmol) of EDC.HCl were added and the reaction mixture was stirred over night at rt. The product was purified by column chromatography (20 g silica gel; heptane/EtOAc 4:1) to yield 113 mg (81%) product as a colorless viscous oil. MS (ISP) 463.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259183B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-c2fa6844900842c89829a65ba88cae4f |
| Source note | uspto-grants-2007_08 |