1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → 5-Fluoro-1H-indole-7-carboxylic acid (4-tert-butyl-benzyl)-phenethyl-amide

참여 물질

반응 단계

66 mg (0.33 mol) of 5-fluoro-1H-indol-7-carboxylic acid, 80 mg (0.30 mmol) of (4-tert-butyl-benzyl)-2-phenyl-ethyl-amine and 63 mg (0.33 mmol) of EDC.HCl were dissolved in 3 ml DCM. The reaction mixture was stirred at rt over night. The solvent was evaporated and the residue was purified by column chromatography (20 g silica gel; heptane/EtOAc 7:3) to yield 85 mg (66%) product as a light yellow viscous oil. MS (ISP) 429.4 (M+H)+.

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