Triphenylphosphine → HCID 90694177, compound

Participants

Reaction Steps

To a solution of 175 mg (0.5 mmol) of 1H-indole-7-carboxylic acid (4-tert-butyl-benzyl)-(2-hydroxy-ethyl)-amide, 91 mg (0.55 mmol) of 2-hydroxy-benzotrifluoride and 144 mg (0.55 mmol) of triphenyl phosphine in 5 ml THF were added dropwise 88 μl (0.55 mmol) azodicarboxylic acid diethyl ester at 0° C. The reaction mixture was stirred at rt over night. The solvent was evaporated and the residue purified by column chromatography (50 g silica gel; diethyl ether/heptane 1:1) to yield 172 mg (70%) product as a white solid. MS (ISP) 495.5 (M+H)+.

Provenance & Evidence