4-((6-(Acryloyloxy)hexyl)oxy)benzoic acid → HCID 58935103, compound

Participants

Reaction Steps

To a solution of 42.2 g (0.20 mole) of 4-Hydroxy-benzoic acid ethoxymethyl ester (15) in 520 ml of dichloromethane were added 58.3 g (0.2 mole) of 4-(6-acryloyloxy-hexyloxy)-benzoic acid (5) and 2.4 g (0.02 mole) of 4-N,N-dimethylaminopyridine under N2 atmosphere. The mixture was cooled in an ice-water bath. After few minutes 41.15 g (0.2 mole) of N,N-dicyclohexyl carbodiimide were added. Then the ice-water bath was removed. It was stirred at room temperature under N2 for one night. Then the mixture was filtered and extracted twice with 300 ml of hydrochloric acid (2.4 M).

Provenance & Evidence