4-((6-(Acryloyloxy)hexyl)oxy)benzoic acid → HCID 69492436, compound

Participants

Reaction Steps

15.7 g (0.076 mole) of N,N-dicyclohexyl carbodiimide were added to a solution of 18.7 g (0.076 mole) of 4-hydroxycinnamic acid ethoxymethyl ester (23) (90% pure), 22.2 g (0.076 mole) of 4-(6-acryloyloxy-hexyloxy)-benzoic acid (5) and 0.93 g (0.0076 mole) of 4-N,N-dimethylaminopyridine in 200 ml of dichloromethane, cooled in an ice-water bath. After two hours the ice-water bath was removed. The mixture was stirred at room temperature overnight. Then it was filtered through a silica pad and the solvent was evaporated. 15 g of the product (40%) were obtained after crystallization from ethanol.

Provenance & Evidence