反应详情

Sodium hydroxide, 6.4 g (161 mmol), was dissolved in 100 mL methanol under nitrogen at room temperature, and α-toluenethiol, 9.52 mL (10 g, 80.5 mmol), was added. After the resulting mixture was stirred for 5 minutes, 2-(4-bromobenzenesulfonyloxy)ethyl tetrakis(2-chloroethyl)phosphorodiamidate, 80.5 mL of 1 M solution in toluene (80.5 mmol), was added with stirring. A precipitate formed within 1 minute of the addition, and stirring was continued. Analysis of the reaction after 2 hours showed that the reaction was nearly complete, and stirring was continued overnight at room temperature. Analysis then showed that the reaction was complete, and stirring was stopped and the reaction mixture allowed to stand and then filtered to remove the precipitated sodium 4-bromobenzenesulfonate. The methanol was removed from the filtrate by evaporation and the residue was dissolved in 250 mL isopropyl acetate. The isopropyl acetate solution was washed with aqueous sodium hydroxide (100 mL of 1 M), water (100 mL), and brine (100 mL), and was then dried over anhydrous sodium sulfate and filtered. The isopropyl acetate was removed by vacuum evaporation to give an oil, which was dried under vacuum at 40° C. overnight, giving 40.4 g of α-[[2-[[bis[bis(2-chloroethyl)amino]phosphinyl]oxy]ethyl]thio]toluene as an orange oil containing residual toluene. HPLC analysis of the product showed a purity of 96.8%. 1H NMR:

1. stirringwith stirring
2. customA precipitate formed within 1 minute of the addition
3. stirringstirring
4. customAnalysis of the reaction after 2 hours
5. stirringstirring
6. waitwas continued overnight at room temperature
7. stirringstirring
8. filtrationfiltered
9. customto remove the precipitated sodium 4-bromobenzenesulfonate
10. customThe methanol was removed from the filtrate by evaporation
11. dissolutionthe residue was dissolved in 250 mL isopropyl acetate
12. washThe isopropyl acetate solution was washed with aqueous sodium hydroxide (100 mL of 1 M), water (100 mL), and brine (100 mL)
13. dry with materialwas then dried over anhydrous sodium sulfate
14. filtrationfiltered
15. customThe isopropyl acetate was removed by vacuum evaporation
16. customto give an oil, which
17. customwas dried under vacuum at 40° C. overnight