2-Aminothiazole → HCID 9884180, compound

Participants

Reaction Steps

A solution of 2-(6-chloropyridin-3-yl)-3-cyclopentylpropionic acid (Preparation 1, 0.56 g, 2.2 mmol), TBTU (1.41 g, 4.4 mmol), HOBt (0.45 g, 3.3 mmol), NEt3 (0.31 mL, 2.2 mmol), and thiazol-2-ylamine (0.44 g, 4.4 mmol) in anhydrous DMF (23 mL) was stirred at 20° C. for 16 h. The reaction mixture was diluted with EtOAc, before being washed with 2 M Na2CO3, H2O, and brine. After drying (Na2SO4), the organic phase was filtered and concentrated to give the title compound: RTA=3.82 min; m/z (ES+)=336.1 [M+H]+.

Provenance & Evidence