2-Thiazolamine, 5-bromo- → HCID 86594354, compound

Participants

Reaction Steps

Condensation of (E)-3-cyclopentyl-2-(6-methylsulfanylpyridin-3-yl)acrylic acid (Preparation 3, 64 mg, 0.24 mmol) with 5-bromothiazol-2-ylamine (218 mg, 1.22 mmol), by the protocol described in EXAMPLE 5, yielded (E)-N-(5-bromothiazol-2-yl)-3-cyclopentyl-2-(6-methylsulfanylpyridin-3-yl)acrylamide: RTA=4.28 min; m/z (ES+)=426.2 [M+H]+. This compound (61 mg, 144 μmol) was oxidised, employing the procedure described in EXAMPLE 35, to give the title compound: RTA=3.91 min; m/z (ES+)=499.2 [M+MeCN+H]+.

Provenance & Evidence