5-Fluoro-1,3-thiazol-2-amine hydrochloride → (E)-3-cyclopentyl-2-(6-ethylsulfanylpyridin-3-yl)-N-(5-fluorothiazol-2-yl)acrylamide

Participants

Reaction Steps

Condensation of (E)-3-cyclopentyl-2-(6-ethylsulfanylpyridin-3-yl)acrylic acid (Preparation 4, 215 mg, 0.78 mmol) with 5-fluorothiazol-2-ylamine hydrochloride (Preparation 21, 240 mg, 1.55 mmol), by the protocol described in EXAMPLE 5, yielded (E)-3-cyclopentyl-2-(6-ethylsulfanylpyridin-3-yl)-N-(5-fluorothiazol-2-yl)acrylamide: m/z (ES+)=378.2 [M+H]+. Oxidation of this thioether (22 mg, 60 μmol), by the protocol described in EXAMPLE 55, gave the title compound: RTA=3.50 min; m/z (ES+)=394.2 [M+H]+.

Provenance & Evidence