Dimethyl Sulfoxide → HCID 178522583, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-cyclopentyl-2-(6-fluoropyridin-3-yl)-N-thiazol-2-ylpropionamide (EXAMPLE 14, 350 mg, 1.1 mmol) and NaSMe (1.53 g, 22.0 mmol) in anhydrous, degassed DMSO (4 mL) was stirred at 160° C. (bath) for 1 h. On cooling, the mixture was partitioned between EtOAc (50 mL) and 1M HCl (50 mL). The organic layer was washed with H2O (20 mL) and brine (50 mL). The solvent was evaporated and the residue recrystallised (EtOAc-1H) to give the title compound: RTA=3.24 min; m/z (ES+)=334.2 [M+H]+.

Provenance & Evidence