Propanoic acid, 3-iodo- → HCID 10476400, compound

HRID 855552Notes

Reaction equation

HRID 855552 reaction equation
[CH:1]1([CH2:6][CH:7]([C:16]2[CH:17]=[N:18][C:19]([SH:22])=[CH:20][CH:21]=2)[C:8]([NH:10][C:11]2[S:12][CH:13]=[CH:14][N:15]=2)=[O:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.I[CH2:24][CH2:25][C:26]([OH:28])=[O:27]>>[CH:1]1([CH2:6][CH:7]([C:16]2[CH:21]=[CH:20][C:19]([S:22][CH2:24][CH2:25][C:26]([OH:28])=[O:27])=[N:18][CH:17]=2)[C:8](=[O:9])[NH:10][C:11]2[S:12][CH:13]=[CH:14][N:15]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8856Propanoic acid, 3-iodo-HCID 178522583HCID 178522583, compound

Product 1

HCID 10476400HCID 10476400, compound

Procedure

3-Cyclopentyl-2-(6-mercaptopyridin-3-yl)-N-thiazol-2-ylpropionamide (EXAMPLE 66, 100 mg, 300 μmol) was reacted with 3-iodopropionic acid (60 mg, 300 mol), employing the procedure described in Step 1 of EXAMPLE 67, to furnish the title compound: RTA=3.61 min; m/z (ES+)=406.4 [M+H]+.

Sources & evidence

ORD record
ord-c5eda344e7fa4c5c8c7b9c8dae559dc3
Source dataset
uspto-grants-2007_08
Patent number
US07262196B2

Reaction notes

Loading…