Trifluoroacetic acid → HCID 10043381, compound

Participants

Reaction Steps

A stirred solution of (E)-tert-butyl {5-[1-(5-chlorothiazol-2-ylcarbamoyl)-2-cyclopentylvinyl]pyridin-2-yl}carbamate (Preparation 18, 212 mg, 473 μmol) in CH2Cl2 (5 mL) was treated with TFA (5 mL, 65.1 mmol). After 2 h, the mixture was evaporated to dryness, then EtOAc (60 mL) was added. The EtOAc solution was washed with H2O-saturated aqueous NaHCO3 (1:1, 20 mL) and brine (20 mL), before being dried (MgSO4). Filtration and solvent evaporation gave a residue that was dissolved in a minimal amount of Et2O. IH was added to the Et2O solution to precipitate a solid, which was collected and dried to furnish the title compound: RTA=3.07 min; m/z (ES+)=349.2 [M+H]+.

Provenance & Evidence