tert-Butyl N-(1,3-dihydro-1,3-dioxoisoindolyl) carbonate → (S)-1-Boc-3-methylpiperazine

Participants

Reaction Steps

A solution of (2S)-2-methylpiperazine (3.8 g, 38 mmol) and N-(tert-butyloxycarbonyloxy)phthalimide (10 g, 38 mmol) in dichloromethane (100 mL) was stirred at room temperature for 3 hours. The mixture was washed with 2N sodium hydroxide solution, the organic solution dried over magnesium sulphate, and concentrated in vacuo to afford the title compound as a clear oil, 4.31 g.

Provenance & Evidence