Ammonia → Ammonia

HRID 855605Notes

Reaction equation

HRID 855605 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[CH:4][N:3]=1.[NH3:9]>>[NH3:3].[NH2:9][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 5817964-Chloro-6-methylpyrimidine

Product 2

HCID 222AmmoniaHCID 5728526-Methylpyrimidin-4-amine

Conditions

Temperature
100 °C

Procedure

A mixture of 4-chloro-6-methylpyrimidine (Recl. Trav. Chim. Pays-Bas. 84; 1965, 1101-1106) (1 g, 7.81 mmol) and 0.88 ammonia (25 mL) were heated in a sealed vessel at 100° C. for 18 hours. The cooled mixture was concentrated in vacuo and the residue purified by column chromatography on silica gel using dichloromethane:methanol:0.88 ammonia (95:5:0.5) as eluant to give the title compound, 560 mg.

Workup

  1. concentrationThe cooled mixture was concentrated in vacuo
  2. customthe residue purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-192af16311f64cbb9332dd1db345389b
Source dataset
uspto-grants-2007_08
Patent number
US07262192B2

Reaction notes

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