HCID 15211974, compound → HCID 69114800, compound

Participants

Reaction Conditions

Reaction Steps

4-Acetyl-3,5-dimethyl-1H-pyrrole-2-carbonitrile (1.38 g, 8.51 mmol) was suspended in 1,1-bis-dimethylamino-3,3-dimethyl-butan-2-one (1.3 mL) and heated at 75° C. for 42 h. The reaction mixture was evaporated to dryness and the residue was purified by SiO2 chromatography (heptane/EtOAc) to afford the title compound (1.2 g, 65%) as a pale tan solid. 1H-NMR (DMSO-d6) δ: 2.21 (s, 3H, CH3), 2.31 (s, 3H, CH3), 3.32 (s, 6H, CH3), 5.22 (d, 1H, J=12.4 Hz, CH), 7.47 (d 1H, J=12.4 Hz, CH), 11.96 (br. s, 1H, NH).

Provenance & Evidence