3-cyclopropyl-1H-pyrazol-5-amine → 2-Chloro-6-(2-chlorophenyl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-4-pyrimidinamine

Participants

Reaction Steps

2,4-Dichloro-6-(2-chloro-phenyl)-pyrimidine (180 mg, 0.694 mmol) and 5-cyclopropyl-1H-pyrazol-3-ylamine (128 mg, 1.04 mmol) was taken into 3 ml of ethanol. The reaction was stirred at room temperature for 4 days. The reaction was evaporated in vacuo and the crude product purified by flash chromatography (SiO2) eluting with ethyl acetate/hexane (1:1) to afford 93 mg of the desired product. HPLC (C18 column) Rt 6.23 mins.; MS m/z 346.1 (M+H) 344.1 (M−H)

Provenance & Evidence