HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 5-(4-Methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Benzenepropanoic acid, 4-methoxy-beta-oxo-, ethyl ester | HCID 76150 | — |
| Reactant | 3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-one | HCID 15283519 | — |
| Product | 5-(4-Methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one | HCID 605366 | 67% |
Reaction Steps
The starting material was prepared using an analogous procedure to that described for the synthesis of 3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-one in Example 9. Ethyl-4-methoxybenzoylacetate (1 g, 4.5 mmol) was reacted with hydrazine hydrate (218 μl, 4.5 mmol) to give 3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-5-one (570 mg, 67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07262201B1 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-811a42c16e6949a19fc5de471fb43827 |
| Source note | uspto-grants-2007_08 |