HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 6-Methoxy-7-(3-morpholinopropoxy)-4-(5-(3-pyridyl)pyrazol-3-yloxy)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline | HCID 11823941 | — |
| Reactant | 3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-5-one | HCID 12448383 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Methoxy-7-(3-morpholinopropoxy)-4-(5-(3-pyridyl)pyrazol-3-yloxy)quinazoline | HCID 17942758 | 59.5% |
Reaction Steps
Using an analogous procedure to that described for Example 9, 4-chloro-6-methoxy-7-(3-morpholinopropoxy)quinazoline (134 mg, 0.4 mmol), (prepared as described for the starting material in Example 2), was reacted with 3-(3-pyridyl)-4,5-dihydro-1H-pyrazol-5-one (161 mg, 1 mmol) in the presence of sodium hydride (40 mg, 1 mmol, prewashed with THF) in DMF (3 ml) to give 6-methoxy-7-(3-morpholinopropoxy)-4-(5-(3-pyridyl)pyrazol-3-yloxy)quinazoline (110 mg, 59%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07262201B1 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-f41d974cf08d420da5afae02e4e4e39d |
| Source note | uspto-grants-2007_08 |