HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 9957456, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 5-(4-Chloro-phenyl)-2,4-dihydro-pyrazol-3-one | HCID 4778793 | — |
| Reactant | 4-Chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline | HCID 11823941 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 9957456 | HCID 9957456 | 73% |
Reaction Steps
Using an analogous procedure to that described for Example 9, 4-chloro-6-methoxy-7-(3-morpholinopropoxy)quinazoline (140 mg, 0.415 mmol), (prepared as described for the starting material in Example 2), was reacted with 3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-5-one (202 mg, 1.04 mmol) in the presence of sodium hydride (41.5 mg, 1.04 mmol, prewashed with THF) in DMF (2.5 ml) to give 4-(5-(4-chlorophenyl)pyrazol-3-yloxy)-6-methoxy-7-(3-morpholinopropoxy)quinazoline (150 mg, 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07262201B1 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-8e0072a9367c41b3a26b2728a3094443 |
| Source note | uspto-grants-2007_08 |