HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 9890536, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline | HCID 11823941 | — |
| Reactant | 5-(Pyridin-4-yl)-2,4-dihydro-3H-pyrazol-3-one | HCID 13268957 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 9890536 | HCID 9890536 | 48% |
Reaction Steps
Using an analogous procedure to that described for Example 9, 4-chloro-6-methoxy-7-(3-morpholinopropoxy)quinazoline (200 mg, 0.59 mmol), (prepared as described for the starting material in Example 2), was reacted with 3-(4-pyridyl)-4,5-dihydro-1H-pyrazol-5-one (240 mg, 1.5 mmol) in the presence of sodium hydride (59 mg, 1.5 mmol, prewashed with THF) in DMF (3 ml) to give 6-methoxy-7-(3-morpholinopropoxy)-4-(5-(4-pyridyl)pyrazol-3-yloxy)quinazoline (130 mg, 48%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07262201B1 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-2463644ddd6f4bd0a9a876283f73c098 |
| Source note | uspto-grants-2007_08 |