4-Chloro-6,7-dimethoxyquinazoline → HCID 17942759, compound

HRID 855720Notes

Reaction equation

HRID 855720 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:16][C:17]1[CH2:21][C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[N:19][N:18]=1>>[ClH:1].[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][N:3]=[C:2]2[NH:16][C:17]1[CH:21]=[C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[NH:19][N:18]=1

Participants

3

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 12291239HCID 12291239, compound

Product 1

HCID 17942759HCID 17942759, compoundYield 94%

Procedure

Using a procedure analogous to that described in Example 15, 4-chloro-6,7-dimethoxyquinazoline (224 mg, 1 mol), (prepared as described for the starting material in Example 1), was reacted with 3-amino-5-phenyl-4H-pyrazole (183 mg, 1.16 mol) to give 6,7-dimethoxy-4-(5-phenylpyrazol-3-ylamino)quinazoline hydrochloride (328 mg, 94%).

Workup

  1. custom(prepared

Sources & evidence

ORD record
ord-e9e6c541a2544de1a669f2094f7fe0a5
Source dataset
uspto-grants-2007_08
Patent number
US07262201B1

Reaction notes

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