5-(4-Methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one → HCID 178488515, compound

Participants

Reaction Steps

Using a procedure analogous to that described in Example 15, 4-chloro-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazoline (140 mg, 0.435 mol), (prepared as described for the starting material in Example 15), was reacted with 3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-5-one (100 mg, 0.52 mol), (prepared as described for the starting material in Example 10), to give 6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)-4-(5-(4-methoxyphenyl)pyrazol-3-yl)quinazoline (174 mg, 84%).

Provenance & Evidence