Methanol → HCID 178465946, compound

Participants

Reaction Steps

2.4 g (5 mmol) 1,5-diacetyl-3-[4-nitrophenyl-(1-methyl-piperidin-4-ylamino)-methylidene]-2-indolinone are dissolved in 40 ml of tetrahydrofuran (THF), 30 ml of methanol and 30 ml of ethyl acetate, combined with 250 mg Raney nickel and hydrogenated for 6 h at ambient temperature at a pressure of 50 psi. Then 20 ml of dimethylformamide are added in order to dissolve the precipitate formed and hydrogenation is continued for 2 h. Then the catalyst is filtered off and the solution is evaporated down.

Provenance & Evidence