Hydrochloric Acid → HCID 58936500, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (6-chloro-3-cyano-5-fluoro-pyridin-2-yl)-acetic acid methyl ester (9.36 g, 40.9 mmol), as prepared in the previous step, 4.0 M HCl (aq) (256 mL) and dioxane (51 mL) was vigorously stirred at 65° C. for 2 h. The homogeneous amber solution was then allowed to cool to rt, extracted with DCM (3×100 mL), dried (Na2SO4) and concentrated under reduced pressure at 45° C. to provide the title compound as a clear, dark amber oil (7.40 g, 84%). 1H-NMR (300 MHz, CDCl3) δ 7.75 (d, 1H), 4.11 (s, 2H).

Provenance & Evidence