HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 855797Generated: October 29, 2026
Oxalyl chloride → 6-Methoxy-7-nitroquinazoline-2,4(1H,3H)-dione
https://huagongshe.com/reaction/855797
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Amino-5-methoxy-4-nitrobenzamide | HCID 68806743 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Methoxy-7-nitroquinazoline-2,4(1H,3H)-dione | HCID 68804811 | 100% |
Reaction Steps
108 mg (0.5 mmol) of 2-amino-5-methoxy-4-nitrobenzamide were dissolved in 5 ml of tetrahydrofuran and 5 ml of chloroform, and oxalyl chloride (solution in toluene) was added. The mixture was stirred at 60° C. for 5 hours and then concentrated in vacuo. Addition of toluene was followed by renewed concentration. 120 mg (100%) of the desired product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07262220B2 |
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| Source dataset | uspto-grants-2007_08 |
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| ORD ID | ord-790bbb3f2e5843329c85dbcece6f39b2 |
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| Source note | uspto-grants-2007_08 |
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